Posts Tagged ‘Aging’

Posted: May 29, 2012 by Wildcat in Uncategorized
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Supercentenarians are persons who have lived beyond the age of 110. Currently there are only about 80 such known individuals in the world whose age is verified. These people represent the limit of human lifespan. For a variety of reasons not fully understood but including lifestyle choices, genetic variants, and chance, these individuals have escaped the usual causes of death including cancer, heart disease and stroke. However, eventually they too die, with the world record holder being Jeanne Calment who survived until age 122. In a newly published review Drs. Stephen Coles and Thomas Young of the UCLA Gerontology Research Group point out what it may be that is killing supercentenarians: amyloidosis. Amyloidosis is a disease state hallmarked by the deposition of fibers of abnormally clumped masses of transthyretin. The protein transthyretin normally acts to carry thyroid and other hormones. Mutations in the gene make the fibers abnormally sticky and they tend to clump into long fibers which are deposited in multiple organs. (via Is Amyloidosis the Limiting Factor for Humans Lifespan?)

Posted: May 25, 2012 by Wildcat in Uncategorized
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Getting smarter while getting older Brains that maintain healthy nerve connections as we age help keep us sharp in later life. An Age UK-funded project at the University has found that older people with robust brain wiring – that is, the nerve fibres that connect different, distant brain areas – can process information quickly and that this makes them generally smarter. According to the findings, joining distant parts of the brain together with better wiring improves mental performance, suggesting that intelligence is not found in a single part of the brain.

Getting smarter while getting older | News | News and events

Posted: May 23, 2012 by Wildcat in Uncategorized
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It is often noted that life expectancy roughly doubled during the 20th century, but that statistic is an unhelpful merger of two phases. Until World War II, gains in life expectancy were achieved mostly via a progressive lowering of mortality rates in infancy and childbirth; thereafter, the ages at which the most progress has been made are middle-age and above. Most demographers predict that these more recent gains, which have averaged roughly two years per decade, will continue for some time, at least so long as the current rise in obesity and its associated diseases is substantially curtailed by dietary, lifestyle and medical advances. This will have a dramatic impact on the world economy; the nature of that impact will depend heavily on choices we make concerning wealth distribution. (via Science: Making Sure That Health and Wealth Keep Pace with Extended Life Expectancy | UA Magazine)

Posted: May 21, 2012 by Wildcat in Uncategorized
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So far as we know, the last hundred years have been the most radical period of life extension in all of human history. At the turn of the twentieth century, life expectancy for Americans was just over 49 years; by 2010, that number had risen to 78.5 years, mostly on account of improved sanitation and basic medicine. But life extension doesn’t always increase our well-being, especially when all that’s being extended is decrepitude. There’s a reason that Ponce de Leon went searching for the fountain of youth—-if it were the fountain of prolonged dementia and arthritis he may not have bothered. (via Radical Life Extension Is Already Here, But We’re Doing it Wrong – Ross Andersen – Health – The Atlantic)

Posted: April 21, 2012 by Wildcat in Uncategorized
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Researchers identify key genes that switch off with ageing, highlighting them as potential targets for anti-ageing therapies Researchers at King’s College London, in collaboration with the Wellcome Trust Sanger Institute, have identified a group of ‘ageing’ genes that are switched on and off by natural mechanisms called epigenetic factors, influencing the rate of healthy ageing and potential longevity. The study also suggests these epigenetic processes – that can be caused by external factors such as diet, lifestyle and environment – are likely to be initiated from an early age and continue through a person’s life. The researchers say that the epigenetic changes they have identified could be used as potential ‘markers’ of biological ageing and in the future could be possible targets for anti-ageing therapies.

Ageing genes discovered

Posted: April 5, 2012 by Wildcat in Uncategorized
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must watch ! 86-year old Johanna Quaas demonstration on PB – “Turnier Der Meister” Cottbus 2012 (by LieveDaffy)


    • Imagine an intervention, such as a pill, that could significantly reduce your risk of cancer. Imagine an intervention that could reduce your risk of stroke, or dementia, or arthritis. Now, imagine an intervention that does all these things, and at the same time reduces your risk of everything else undesirable about growing older: including heart disease, diabetes, Alzheimer and Parkinson disease, hip fractures, osteoporosis, sensory impairments, and sexual dysfunction. Such a pill may sound like fantasy, but aging interventions already do this in animal models. And many scientists believe that such an intervention is a realistically achievable goal for people. People already place a high value on both quality and length of life, which is why children are immunized against infectious diseases. In the same spirit, we suggest that a concerted effort to slow aging begin immediately – because it will save and extend lives, improve health, and create wealth.
    • The experience of aging is about to change. Humans are approaching old age in unprecedented numbers, and this generation and all that follow have the potential to live longer, healthier lives than any in history. These changing demographics also carry the prospect of overwhelming increases in age-related disease, frailty, disability, and all the associated costs and social burdens. The choices we make now will have a profound influence on the health and the wealth of current and future generations.

      What we have in mind is not the unrealistic pursuit of dramatic increases in life expectancy, let alone the kind of biological immortality best left to science fiction novels.Rather, we envision a goal that is realistically achievable: a modest deceleration in the rate of aging sufficient to delay all aging-related diseases and disorders by about seven years.This target was chosen because the risk of death and most other negative attributes of aging tends to rise exponentially throughout the adult lifespan with a doubling time of approximately seven years.Such a delay would yield health and longevity benefits greater than what would be achieved with the elimination of cancer or heart disease.And we believe it can be achieved for generations now alive.